XDA Senior Member buxtahuda has posted not one, but several tear down videos and methods compiled from a number of other users for the Transformer Prime. The aim of these videos is not only to give users unrestricted access to the innards of their expensive tablet, but also methods to help users fix a number of issues.
The issues that are specifically dealt with are the legendary GPS issues, along with WiFi connectivity issues and light leakage. Buxtahuda has compiled methods from around XDA, to which he gives complete and proper credits for in his thread. Each method comes complete with screen shots at least and a couple have full videos explaining what is what, and how to complete the mod it is intended for. Obviously, any user who follows any of these methods does so at his or her own risk, as modifications at the hardware level can be very dangerous and can cause irreparable damage to the Prime.
Additional information, all the videos, and the full tutorial can be found in the tear down thread. As stated above, be extraordinarily careful when performing any of these hardware hacking methods.