I'm nearly 5'4 and my hands are small — not abnormally small, but small. They're so small that I could never palm a women's basketball, and my fingers barely stretch a full octave when I play piano.
I can palm the iPad Mini with one hand, but it's a strain. I could grip just the side of it, but even at 10.88 ounces my hand would grow tired without some other support. But it's too small to grip with both hands, unlike my iPad 2.
And like my iPhone 4S, it's slippery. I don't think it'd be long before the strain of palming the device combined with the slick material would result in me clumsily dropping, then cracking it.
Putting that issue aside, I don't know what I'd use an iPad this size for. If I want to surf the web, write an article, or watch something, I'd still rather have a bigger screen. If I want something slightly smaller than the iPad 2, I'll either use my iPhone (which I now have safely tucked inside a cover) or get a cheaper device that wouldn't make my heart skip a beat if I dropped it.
Am I'm nitpicking here? Sure. If someone handed me a free iPad Mini and told me to keep it, I'd happily oblige. Overall, it's gorgeous. It's sleek, relatively light, and fairly thin.
But if women were the users Apple had in mind for the Mini, I think they could have taken it in half an inch more.